Studies On Immunoglobulin G In Central Nervous System

The Central nervous system(CNS) has long been regarded as "immunologically privileged site" for the blood-brain barrier( BBB) and lack of lymphatic vessels in brain parenchyma. But this concept has being challenged by increasing experimental evidences with progresses in neuroscience. The present thesis has studied on the immunoglobulin G(IgG) existed in CNS, both endogenous and exogenous IgG. The Mechanisms underlying the uptake and transport of IgG by neurons, accesses of IgG to CNS, especially the effects of the exogenous antibody against motoneuron( Ab- Mn) on CNS, using histochemical and immunocytochemical techniques, and in situ hybridization, electron microscopy for immunocytochemistry, and some techniques of immunology and neuropsychology. It consists of following five parts:I. Demonstration of IgG-like immunoreactivity in CNS Wistar rats, mice and rabbits were studied for demonstration of endogenous IgG-like immunoreactivity( IgG...