Study On Defects Of Erythrocytes In Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria ( PNH) is an acquired hemolytic disorder commonly seen in North China. The foundamental nature of the disease is still not well defined and many questions as to mechanism of hemolysis remain unanswered. One of the main obstacles in study is the intermingling of different red cell populations in patients' peripheral blood. In the present investigation, we tried to explore the abnormalities of PNH erythocytes ( PNHE) , which were separated into different categories. Our purpose is to identify the defects of PNHE belonging to different categories and to elucidate their individual abnormalities which may lead to hemolysis. The...