| More recognition of biological characteristic of breast cancer leaded to a conception that breast cancer was a systemic disease at its beginning. This conception was approved and received wildly. Two of large prospective randomized clinical trials have made significant contributions toward breast conserving treatment as the first choice forâ… ï½žâ…¡stages invasive breast cancer recently. Following the improvement of equipment and technique of minimally invasive surgery, mastoscopy surgery has developed rapidly. There were several reports about endoscopic surgery in breast cancer by now, but identical criterion of its outcome, uniform technique of operation, sufficient evidence of oncologic safety and large randomized clinical trial of long-term outcomes was lack in recent. The aim of this study is to evaluate the safety of endoscopy in breast cancer, to investigate the technique of operation about endoscopic axillary lymph node dissection by liposuction, endoscope-assisted modified radical mastectomy with small incision, to identify the feasibility of thoracoscopic internal mammary sentinel node biopsy and internal mammary chain excision in animal model, to confirm the relevant factors of skin-flap involvement and extension of skin excision by histological observation, to summarize the applicability and contraindication about endoscopic surgery in breast cancer and its criterion of management.Materials, Methods and main results:1. The feasibility and safety of axillary lymph node dissection by endoscopy and thoracoscopic internal mammary sentinel node biopsy and internal mammary chain excision in animal modelAfter intubated and kept anesthetized with ketamine, Methylene blue 4ml was injected subdermally into the upper nipple of small type pig. Working space for endoscopy was made by ultracision (Ethicon, USA) bluntly or sharply and was kept by filling with CO2. Results: Working space for endoscopy could be made easily by two methods. The main...
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