The Ultrasonophic Study Of Ultrasonography Diagnostics On Hepatic Fibrosis Rats

Liver biopsy is the golden standard for hepatic fibrosis or cirrhosis, but its clinical application is limited because of its invasiveness. Ultrasonography diagnosis is a non-invasive method. If ultrasonography measurement could diagnose chronic liver disease before cirrhosis is pathologically occurred (stage of hepatic fibrosis), it would be helpful to investigate prognosis to prevent cirrhotic process or reverse the process of hepatic fibrosis. Purpose:(1) To assess the value of quantitative gray ultrasonography on the hepatic fibrosis by computer associatied imaging analysis. Hemodynamic changes at different stages of hepatic fibrosis were evaluated with color Doppler flow imaging (CDFI). To find out the relationship between noninvasive ultrasonography quantitative scoring system and the degree of hepatic fibrosis.(2) The hepatic circulation index (HCI) and A/P ratio at different stages ofhepatic fibrosis was calculated to assess liver reserve function.(3) Peripheral blood serum level of fibrosis marker were measured by radioimmunoassay (RIA) in control group and study groups. At the same time, peripheral blood serum liver function markers were examined by automatic biochemical analyzing system so as to find out...