Study On The Cardiovascular Protective Effects Of Resveratrol

Coronary heart disease (CHD) has higher mortality and mortality in the world. Epidemiologic survey disclosed, French have a very low mortality rate due to CHD despite having a high-fat diet and smoking habbits. This so-called 'French paradox' has been attributed in part to wine consumption, particularly red wine. Resveratrol (trans-3,4',5- trihydroxystilbene), a naturally occurring phenolic compound abundantly found in grape skins and in wines, has been thought to be responsible for the cardiovascular benefits associated with moderate wine consumption. Resveratrol has extensive physiological pharmacological effects, which include antioxygen, cleaning free radical, antiplatelet, regulating blood fat, preventing artherosclerosis, anti-inflammatory, anti-eumycete, anti-tumor, and hepatoprotective properties. This experiment has two aspects: we will study vasodilatation of resveratrol in aortic artery and cardioprotection in ischemia-reperfusion.1.Vasodilatation and underlying mechanism of resveratrol on abdominal aortic artery in the rat Isolated aortic ring was perfused and the tension of the vessel was measured, results indicated that resveratrol relaxed the aortic artery in an endothelium dependent and independent manner, the previous mechanism of vasodilation maybe is via NO system and K_ATP⁺, BK_Ca...