The Study On Relationship Between RhoA Gene Expression And Invasion And Metastasis In Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is one of the most frequent human cancers worldwide and has been ranked as the second cancer killer after gastric cancer in China since the 1990s. At present, surgical operation is the most major treatment to it. Although the prognosis of HCC has already improved along with liver transplantation and the advances of the diagnostic radiology and the surgical techniques, the relapse rate after operation is still very high. It is still not realistic depending merely on the improvement of surgical mode to bring about a striking treatmental effect. Therefore, the invasiveness of HCC has become a major obstacle to better prognosis and a major target for researchers. Rho proteins are best characterized for their effects on the cytoskeleton and cell adhesion, and these functions will clearly affect cell migration and therefore presumably invasion and metastasis. However, carcinoma invasion is a complex process and involves changes in cell-cell adhesion, cell-matrix adhesion and proteolysis as well as migration. In this article, we would study the potential effect of Rho GTPases on the hepatocellular carcinogenesis and metastasis, and also to explore the role of...