Clinical And Basic Study Of Perioperative Circadian Rhythm And Neuropsychological Status In Patients Undergoing Cardiac Surgery

Clinical and basic study of perioperative circadian rhythm and neuropsychological status in patients undergoing cardiac surgery(â… ) Clinical study of perioperative neuroendocrinological and neuropsychological status in patients undergoing coronaryartery bypass grafting surgeryThe incidence of neuropsychologic deficits after cardiac surgery, including cognitive dysfunction and mood status, has been shown to be as high as 70%, which has significant impact on the patients' prognosis, outcome and long-term life quality. Because the perioperative neuropsychological deficits are the functional changes of the brain, it hasn't been clear whether these changes have endocrinological foundations. The relationship between neuroendocrine variations and neuropsychologic status in patients undergoing cardiac surgery hasn't been reported. Melatonin and cortisol possess a circadian secretion pattern. They involve in modulating the human physiological processes and neuropsychological status, whereas their secretion pattern disorder may lead to many diseases. Neuron-specific enolase is an enzyme mainly localized in neurons. The elevation of serum concentration of NSE was expected as a biochemical marker of cerebral damage. In present study, we investigate circadian rhythms of perioperative melatonin and cortisol secretion and the changes of serum concentration of NSE as well as neuropsychological status in patients undergoing coronary artery bypass grafting surgery. Material and MethodsForty male patients scheduled for elective coronary artery bypass grafting...