The Chemopreventive Effect Of Bicyclol, DDB On Hepatocarcinogenesis And The Reversal Of Multidrug Resistance By Chinese Herb XX

This article comprises two parts: I . The chemopreventive effect of bicyclol and DDB on hepatocarcinogenesis; II. The reversal of multidrug resistance by Chinese herb XX.Part I The chemopreventive effect of bicyclol and DDB on hepatocarcinogenesisBicyclol(4,4' -dimethoxy-2,3,2' ,3' -dimethylene-dioxy-6-hydroxymethyl-6' -carbonyl-bi phenyl), a novel synthetic anti-hepatitis drug, has been licensed to treat HBV infection clinically. Bicyclol was shown to lower the elevated serum transaminase level in chronic HBV patients and was also effective in inhibiting the replication of hepatitis B virus. DDB (Dimethyl dicarboxylate biphenyl) has been widely used to treat viral hepatitis B patients in China since 1983. It is well known that the most frequently causes of HCC (Human hepatocellular carcinoma) are chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections. About 90% of human HCC are associated with hepatitis virus infection. Now, the therapy of both chronic HBV and HCV needs generally a course of long term. If an anti-hepatitis drug has inhibiting or suppressing effect on the development of hepatocarcinogenesis besides its improvement on abnormal liver function and inhibition of hepatitis virus replication, this kind of drug would be of great clinical value. The aim of the present study was to assess whether bicyclol and DDB have chemopreventive effect on hepatocarcinogenesis, and by what mechanisms of both drugs exert their effects on liver carcinogenesis. The main results are summarized as follows. 1. Effects of bicyclol and DDB on hepatocacinogenesis chemopreventionWB-F344 rat liver epithelial cells were chemically transformed by 3MC and TPA. In this two-stage chemical transformation model in vitro, bicyclol and DDB at non-cytotoxic concentrations obviously inhibited the malignancy of WB-F344 cells expressed in decrease of transformed foci and reduction of malignant degree of transformed cells. In the two-stage...