Study Of Molecular Mechanism Of UVB & Oxygen Stress-induced Collagen Type I Degradation And EGF-Induced Cell Migration In Cultured Human Lens Epithelial Cells

Cataract is the most common cause of blindness in the world. About 20,000,000 people in the world are blind caused by cataract. It also is a major ocular disease that causes blindness in china. Cataract is curable only by surgery. Unfortunately, many patients gradually develop the complication of posterior capsule opacification (PCO), arising from stimulated cell proliferation and cell migration within the lens capsule. It is estimated that 12 percent people will develop PCO in one year after surgery and 28 percent in five years post-surgery. Visual acuity(VA) is seriously deseased by PCO but which can not be effectively prevented and treated by now.It is well established that various factors such as UVB and oxidative stress of H₂O₂ can induce cataract and PCO formation. During the process of PCO formation, many growth factors involved in the proliferation and migration of human lens epithelial cells(HLECs). EGF, bFGFand TGF-β that can stimulate...