The Proteomic Study Of UV Irradiation Effect On Skin Cells

As the earth ozonosphere turn thinner, the ultr aviolet (UV) irradiation is becoming more harmful to human being. The skin, our first line of defense from ultraviolet light, bears the majority of photodamage, which results in inflammation, immunity suppression, photoage, and malignancy. The study in this field focus on the pathogenesis of photodamage. The molecular mechanism of the UV effect on skin is associated with lots of factor (gene, proteins) and lots of pathway. Current technology, which could only study single factor or pathway at one moment, could not discuss the photodamage pathogenesis in a global and systematical way, also could not illuminate the interaction between different factors and their pathway.Since the life science has come into the post-genomic era, the scientific study has been paying more attention to the real gene functionexecuter-protein. Proteome means entire protein complement expressedby the genome. Proteomics is the comprehensive analysis of total protein complement in a cells, tissue or biological organ at a given time. Current technology, which still mostly limited to the more abundant proteins, could only detect single or several proteins at one moment, while proteomics techniques could perform biological assays involving measurement of multiple variables in the same time. The goal of proteomics is a comprehensive, quantitative description of protein expression and its changes under the influence of biological perturbations such as disease or drug treatment. Thus proteomics is a global systematical and high-throughput methods for analysis of protein expression.