Augmentation Of The Migratory Ability And Immunological Effect Of Dendritic Cells Loaded With Breast Carcinoma Antigen

Dendritic cells (DCs) are professional antigen-presenting cells, its migration play a crucial role in inducing the initiation and maintenance of T cell-mediated immune responses. After taken up antigen in peripheral tissues, active DCs turn to mature, express MHC class â…¡ and co-stimulatory molecules, and migrate to the T cell zones of secondary lymphoid organs (such as draining lymph node) via the afferent lymphatic. Within the T cell zone, DCs present the information of antigen to naive T cells and stimulate finely tuned antigen-specific immune responses. It has been reported that the absolute number of the DCs found within the draining lymph node represented only a small proportion, when exogenous DCs are immunized by intracutaneous injection. Inefficient migration of DCs to lymphoid organs may lower the frequency of their encounter with T cells. Therefore, it may be possible to improve the anti-tumor immunological efficacy of exogenously transferred DCs to prime immune responses by augmenting their migratory capability.1, Promotion of the migratory ability of mouse bone marrow-derived...