Study Of The Dynamic State Of Centrosome And Telomerase And Their Relation In Rat HCC And Mouse Skin Cancer

Objectives:Carcinogenesis is a very complicated process determined by interactions of multifactors. Although great- progresses have been made in this field, the understanding of the mechanism of carcinogenesis is still limited, with the prognosis of the patients with cancer is poor. Generally, carcinogenesis is closely associated with genetic instability, and the later also has close relations with the development of drug resistance that acts as a major reason failing cancer therapies. Among all the factors leading to genetic instability, centrosome and telomerase have contributed much more to both carcinogenesis and genetic instability, which has attracted more and more attentions. However, the relationship between centrosome and telomerase in carcinogenesis has seldomly reported. This study is to study the roles of centrosome and telomerase in carcinogenesis, and explore the relationship between centrosome and telomerase in this process in particular. Hopefully, the expected results is useful for further understanding the mechanisms of carcinogenesis and is helpful for effectively treating cancer therapeutically and prophylactically.Centrosome is a nonmembranous organelle of 1μm in diameter, consisting of pericentriolar material and a pair of embedded centrioles. It not only acts as a microtubule-organizing center (MTOC), involving in regulation of many microtubule-mediated cellular activities, such as polarity, morphology, mobility, and so on, but also plays pivotal roles in cell cycle regulation, DNA synthesis and repair, and apoptosis. Moreover, recent studies showed that MTOC was found to be involved in cell cycle transition, response to cell stress, and organization of signal transition...