The Related Molecular Biological Study Of Invasive And Metastasis In Human Esophageal Squamous Cell Carcinomas

PART 1THE CLINICAL SIGNIFICANCE OF VASCULAR ENDOTHELIALGROWTH FACTOR AND MATRIX METTALLOPROTEINASE-2EXPRESSION IN HUMAN ESOPHAGEAL SQUAMOUSCELL CARCINOMASObjective: To investigate the expression of VEGF and MMP-2 in tumor tissue of human esophageal squamous cell carcinoma, and their relationship to behaviors of the esophageal squamous cell carcinoma.Methods: A rapid immunohistochemical methed (streptoavidin-peroxidase, S-P) was used to detect VEGF and MMP-2 expression in pathological tisse sections of 76 cases with esophageal squamous cell carcinoma. All patients were treated with operation and without radio- or chemical therapy before operation. The relationship between the expression and the histopathological type, T stage, lymph node metastasis and survival time was analyzed with x~2 test, Kaplan-Meier and Log Rank test.Results: The expression rates of VEGF and MMP-2 in 76 esophageal carcinoma tissues were 57.9% and 56.58%, respectively. The positive expression of VEGF was significantly correlated with the lymph node metastasis, T stage, prognosis and hematogenous tumor metastasis. The 5-year survival rate of patients with VEGF...