The Study Of Functional Changes In Cortex Of Frontal And Parietal Lobes In Parkinson's Disease And Its Mechanism

Parkinson's disease (PD) is a neurodegenerative disorder that usually appears in aged people. The major pathologic hallmark of PD is that the death of most of dopamine neurons in the pars compacta of substantia nigra, with the obvious dopamine deletion in the striatum. Its clinical manifestations include bradykinesia, rigidity and tremor, usually companied with cognitive impairment, mental disorder and other behavioral changes. At present, investigations on the pathologic mechanism of Parkinson's disease have been mainly concentrated on the nigrostriatal system , but some studies confirmed that pathological changes of Parkinson's disease(PD) were accompanied by motor functional changes of the cerebral cortex. Because the frontal and parietal cortex is closely related to basal ganglia, and plays a governing role in cinetic sponsoring and adjusting process, investigation of functional change in this region will be helpful to understand the pathologic changes and clinical manifestation of PD. Investigators used functional imaging equipments such as PET and fMRI to explore the changes of the frontal and parietal cortex of PD patients and confirmed that there were metabolic and functional disturbance in this region. But the above researches were on PD patients, thus there still is a lack of the detail mechanism of the pathological changes in the frontal and parietal cortex of PD. By observing the change of PET/CT and MRS in vivo and cello-molecular biological detection in postmortem of animal models of PD in different period, we studied the...