The Protective Effect And Mechanism Of Small Intestine Ischemic Preconditioning On Myocardial Ischemic And Reperfusion Injury In Rabbits

Objective: The concept of classic ischemic preconditioning(IPC) is refers to a phenomenon that several brief ischemia can reduce the infarct size during the long time ischemia-reperfusion subsequent. It was first described by Murry who showed that IPC decreased the infarct size induced by a 40 minutes of coronary occlusion in a canine model of myocardial ischemia and reperfusion. But the great damage of it limited its' application in clinical. With the development of the sstudy ,Przyklenk discovered the interorgan or remote organ preconditioning(IOPC) of the myocardium: four episodes of 5-minute ischemia and 5-minute reperfusion of circumflex branch can reduce the infarct size of the myocardium who provided by anterior descending branch. The phenomenon of IOPC was demonstrate at small intestine, liver, kidney, brain and skeletal muscle et al. All of the organ above-mentioned can produce myocardial preservation when there have a adapt stimulation of ischemia . so we think there have no variability among different organs about IOPC. But the mechanism of the IOPC is not clear still, so the aim...