The Studies On The Brain Protection Induced By Remifentanil Preconditioning And Its Mechanism In Rats

Since Kitagawa and his colleagues firstly reported the phenomenon that ischemic preconditioning can induce ischemic tolerance in the model of cerebral ischemia in gerbils in 1990, investigators have been keeping on trying to find non-ischemic preconditioning methods, especially drugs , which were expected to be finally applied in clinical practice. We have been devoted to the study in neuroprotection for a long time.While looking for the possible drugs with neuroprotective effects, We also search into the the mechanisms of cerebral ischemic tolerance induced by non-ischemic preconditioning and wish to find some feasible methods for clinical application.Remifentanil is a new ultra-short-acting opioid agonist. Because of its special advantages.remifentanil has been applied to clinic anesthesia widely. Animal experiments demonstrated that remifentanil preconditioning could induced cardioprotection via δ-,κ- and μ-opioid receptors. This differs from ischemic preconditioning, which confers cardioprotection via κ- and δ-, but not μ -opioid receptors. Part of the protective effect of remifentanil may be produced by μ-agonist activity outside the heart. It is lack of scientific foundation that remifentanil preconditioning has brain protection. This study aimed to determine whether remifentanil preconditioning could induce brain protection against ischemia-reperfusion induced injury and, if so, which ORs mediate the effect.