Preliminary Study Of The Relationship Between Human Telomerase Reverse Transcriptase And Carcinogenesis Of Oral Submucous Fibrosis

Background Oral submucous Fibrosis (OSF) is a kind of chronic insidious disease and it predisposes to cancer.Histologically,OSF is characterized by epithelial atrophy and progressive accumulation of collagen fibers in the lamina propria and submucous of the oral mucosa with a progressive loss of vasularity.The majority of patients present with an intolerance to spicy food,rigidity of lip, tongue and palate leading to varying degrees of limitation of opening the mouth and tongue movement.A number of studies provide overwhelming evidence the betel quid is the main aetiological factor for OSF,It has been estimated that there are 600 million betel quid chewers in the world. OSF was reguarded as a precancerous condition by WHO,the malignant transformation rate of OSF was 7.6% over a 17-year period. OSF has become one of the major oral premalignant lesions,Case-control studies showed that the malignant transformation of OSF had been associated with cigarette smoking and betel quid chewing.The pathogenesis for the malignant transformation of OSF is still not known,It may be associated with the carcinogens from areca nut, tobacco, the mutation of p53 gene, the induction of cytokine, the change of a few enzyme such as cyclooxygenase-2, lysyl oxidase, telomerase and inducible nitric oxide synthase, gene ploymorphism, trauma and autoimmune et al, The exact mechanism need to be...