The Influence Of Expression Of Eph On Axonal Sprouting And Synaptic Plasticity In Hippocampus Of Temporal Lobe Epilepsy Rats

Objective:Temporal lobe epilepsy(TLE) is a big proportion of refractory epilepsy in clinical. The main pathophysiological characteristics of temporal lobe epilepsy is axonal sprouting and subsequent synaptic reorganization in hippocampus, which may play a important role in the development and maintenance of epileptogenesis. Recently, axon guidance molecules Eph receptors and their ligand ephrins that provide guidance role to axon outgrowing in the development of CNS existextensively in hippocampus of the adults. But we didn' t know whetherthey contribute to axonal sprouting and synaptic reorganization of hippocampus in TLE. In the development of epilepsy the synapse is abnormal between cell and cell, which established pathological neural circuit. synaptic plasticity in the hippocampus is the base of synaptic reorganization in TLE. Gliosis is resulted in TLE. The synapse consists of the presynaptic and postsynaptic terminals, which in many synapses are surrounded by glial cell. The change of dendritic spine morphology in postsynaptic terminals induced synaptic plasticity. At present,the were no reports about expression of EphA4, EphA5 and their ligand ephrinA3, ephrinA5 in different models of epilepsy. The present work was undertaken in order to study the dynamic changes in the expression of EphA4, EphA5 and their ligand ephrinA3, ephrinA5 in the hippocampus circuits of rats during acute, silent and chronic periods after lithium-chloride and pilocarpine administration, to systematically study their effects on axonal sprouting and synaptic reorganization in TLE, and their role in control of dendritic spine morphology and synaptic plasticity in TLE.