Effects Of Fenofibrate On Proliferation And Apoptosis Of Cultured Human Umbilical Vein Endothelial Cells Induced By Lysophosphatidylcholine

Endothelial cells, a single layer of cells surrounding the vessels lumen, play an important role in maintaining vascular structure and function by the balance beween proliferation and apoptosis. Recent studies showed that the etiology of a variety of cardiovascular diseases was involved in proliferation and apoptosis of endothelial cells. Atherosclerosis (AS) is one of the most common and dangerous diseases. In the pathogenesis of atherosclerostic lesion, the injury of endothelial cells was well known as an intiating event. The published reserches demonstrated that oxidized low density lipoprotein (ox-LDL) acted on the membranes of endothelial cells, which leading to lipid peroxidation. The lipid peroxidation may injure DNA and induced the apoptosis of the endothelial cell. Ox-LDL was considered to play a key role in the endothelial cell injury. Lysophosphatidylcholine (LPC) is the main active component of ox-LDL and play a very important role in the pathogenesis and development of atherosclerosis. In the study, the effects of fenofibrate on proliferation and apoptosis of cultured human umbilical vein endothelial cells (HUVECs) induced by LPC were investigated.Vascular endothelial cells are the barrier between blood and tissue, and can regulate the physiological and pathological processes by synthesizing and releasing many kinds of vascular active substances.