The Study Of Immediate-early Gene C-fos Expression Induced By Experimentally-induced Myopia In Guinea Pig Retina And Its Regulation Of Tyrosine Hydroxylase

Part 1 Changes induced by Form-deprivation myopia in Guinea pig Objective Form-deprivation myopia was induced in guinea pig in this study. To study the effects of facemask on eye growth, refractive and axial length development in guinea pig and observe whether guinea pig is a suitable model animal for experimental myopia. Methods Forty growing Guinea pigs were distribute in four group: one group underwent monocular form-deprivation by facemask for 1 week; one group deprived for 2 weeks; one group recovered for 1 week after 2 weeks' deprivation; and one group untreated for normal control. The refraction and axial length of the eyes were measured after treatments. Results Deprived eyes showed significant development of myopia compare with the contralateral fellow eyes. The deprived eyes developed myopia from -4.5D at 1 weeks to -8.8D at 2 weeks. The refraction and axial length of the deprived eyes increased significantly fellowing the development of myopia (P<0.05). After 1 week's recovery, The refraction and axial length are of no statistical significant differences between the deprived eyes and recovered eyes (P>0.05); Conclusion Form-deprivation myopia can be induced in guinea pig. guinea pig could be used as an effective and economical model of mammal in Form-deprivation myopia.