Combined Transplantation Of HBDNF-Transfected NSCs And HVEGF₁₆₅-Transfected NSCs For Rats Following Traumatic Brain Injury

Traumatic brain injury is now believed to be a progressive degenerative disease characterized by cell loss.Current attempts to promote CNS repair using :replacing affected cell populations(or structural components ) and their connections by neural graft and providing trophic support by the introduction of neurotrophins and/or cytokines to diminish to or prevent progressive neurodegeneration,stimulate neurite outgrowth,guide growth,guide growing axons to their targets and pomote establishment of functional synapses. NSCs have the ability to migrate and integrate through the brain as well as to disseminate a foreing gene product,so gene-transfected NSCs are great significance for development of new therapies for TBI. This study attempted to explore whether transplanting hBDNF-transfected and hVEGF165-transfected NSCs into the rat brain provides sufficient neuroprotection after TBI.1 Transplanted neural stem cells improve neurological function after experimental traumatic brain injury...