| Campylobacter jejuni (C.jejuni) has been recognized as one of the most important causes of acute bacterial gastroenteritis in worldwide, which is also the most frequent infectious agent associated with Guillain-BarréSyndrome (GBS). However, due to the poor understanding of genetic property, virulence factors and pathogenesis of C.jejuni inducing GBS, no effective and feasible measures are now available in prevention of C.jejuni inducing diarrhea and GBS. To solve the problems, in this study, considering that C.jejuni is a changeable and variable intestinal infectious bacterium and taking advantage of the superiority of DNA vaccine inducing specific humoral and cellular immune responses, as well as the characteristics of chitosan enhancing mucosal absorption and slowing release, we designed and constructed successfully C.jejuni polyvalent DNA vaccine with effective mucosa immune response, explored the specific immune responses and immunoprotection in mice challenged with C.jejuni, we also evaluated its safety for peripheral nerves. It would lay a foundation for developing a new C.jejuni vaccine. The topic will be carried out with four parts as follows:...
|
PDF Full Text Request