Ex Vivo Activated Immune Cells Promote Survival And Stimulate Multilineage Hematopoietic Recovery In Myelosuppression Induced By Radio And Chemotherapy

Background:Chemotherapy and radiotherapy are widely used for treatment of cancer and as a part of procedure for bone marrow and stem cell transplantation. However, the efficacy of these therapies is often closely correlated with side effects; the most common side effect is myelosuppression. Mild to modest myelosuppression induced by chemotherapy and radiotherapy usually recovers either spontaneously after discontinuation of the therapy or after therapy with growth factors. But severe myelosuppression rarely recovers and often results in infection, bleeding and even death. Four FDA approved growth factors, G-CSF, GM-CSF, Interleukin-11 and Erythropoietin are routinely used to accelerate recovery of blood production. Although these growth factors are powerful drugs, they are often not effective for severe and chronic myelosuppression , and the recovery of multilineage Hematopoiesis, thrombocytosis in particular, remains a problem to be solved. We...