Bone Marrow Suppression After Chemotherapy Clinical Studies Of Tcm Prevention And Treatment Programs

The author here presented her theoretical and primary clinical studies on the chemotherapy- followed bone marrow depression.In the part of theoretical study, the paper presented and analyzed the opinions of TCM and West Medicine about the etiology, pathogenesis, therapeutic principles and prescriptions of chemotherapy-followed bone marrow depression. It also summarized the general situation of the research on the chemotherapy-followed bone marrow depression especially in the near 10 years.In the part of clinical study, 30 patients with the cancer needed chemotherapy were divided into group A and B randomly. Group A was treated with Nourishing Kidney and Smoothing Blood Chinese Herbs one week before, during and one week after chemotherapy. Group B was treated with granular clonbeg stimulating factor (G-CSF),3-7 days, once leucocytes dropped bellow 3000×109/L after chemotherapy. With these treatments, the times of the patients developed to bone marrow depression in group A was 6 times, while in group B was all the times. Two groups were also studied in contrast in the aspects of clinical symptoms, hemoglobin value, the proportion of clinical effect and medical cost. The results also showed that in the aspect of increasing leucocytes, the effective rate of group A is 76.67%, while of group B is 83.33%, there is no significant difference between the two groups(p﹥0.05). In the aspect of relieving clinical manifestations, such as soreness and weakness in the lumbar region and knees, feverish sensation in the chest, palms and soles, dizziness, night sweat, constipation, black menstruation with clot, the dark purple tongue, group A is superior to group B(all p﹤0.05). It was also found that Integrated Treatment Plan of TCM could alleviate the chemotherapy-followed bone marrow depression, contribute to the smooth finishing of chemotherapy through prevention the decreasing of leucocytes and erythrocyte (p﹤0.05). In the aspect of preventing the decreasing of leucocytes, no significant difference was found between Integrated Treatment Plan of TCM and G-CSF(p﹥0.05) but in the aspect of medical cost, however, the cost of Chinese medicine is much lower than G-CSF. Clinical observation demonstrated that Integrated Treatment Plan of TCM is effective in preventing and alleviating chemotherapy-followed bone marrow depression, contributing to the smooth finishing of chemotherapy and relieving clinical manifestations. It can also decrease medical cost. We believe that Integrated Treatment Plan of TCM has a good prospect of clinical complication.