CD4～+CD25～+ Regulatory T Cells In Human Kidney Transplant Recipients And The Impact Of Immunosuppressive Drugs On Them

Objective: Graft rejection , acute or chronic, occurs inevitably as a consequence of polymorphisms in histocompatibility genes located within the MHC. The immunosuppressive drugs currently used in clinical transplantation are efficacious in countering acute rejection, at the same time they failed to prevent chronic rejection. The induction and maintenance of the transplantation tolerance is the only way for the recipients to avoid the chronic immunosuppressive agents and achieve a long survival. But at present, neither the central nor the peripheral tolerance strategies get great achievement because of the complicated manipulation method or unsure effects. There is now a great degree of consensus that the CD4+CD25+ regulatory T cells(CD4+CD25+Treg) play an important role in both the induction and the maintenance of the transplant tolerance so it is necessary to have intensive investigations on them, including the change of Treg cells and the expression of molecular markers ,CTLA-4 and Foxp3. This study focus on the 3 aspects: 1. The relationship between graft function and the CD4+CD25+Treg in long survival recipients; 2.The impact of immunosuppressive drugs on the CD4+CD25+Treg; 3. The change of the CD4+CD25+Treg after the transplant nephrectomy in recipients suffering from chronic allograft nephropathy (CAN) with...