| Background and Objective Herpes simplex virus (HSV) is the viral agent of genital herpes (GH) in mankind worldwide. Researchs in epidemiology showed seropositive for HSV were increasing obviously in most countries in the past 20 years. GH recurrents easily, which harm the patients heavily. GH expends lots of publical health resource as well as aggravates economic burden. GH in pregnant women may cause deadly infection in newborn children and foetuses. GH also increases the fatalness of HIV-infection in AIDS era. Effective therapy and vaccines are not available at present. Following primary infection, neutralizing antibodies to HSV develop in the serum. Subsequently, some seropositive individuals develop clinically mild recurrent labial or genital lesions, typifying the unique biological property of HSV, namely an ability to recur in the presence of humoral immunity or reactivation of latent infection. The spectrum of disease caused by HSV includes primary and recurrent infections of mucous membranes (e.g., gingivostomatitis, herpes labialis, and genital HSV infections), keratoconjunctivitis, neonatal HSV infection, visceral HSV infections in immunocompromised hosts, HSV encephalitis, Kaposi's varicella-like eruption, and an association with erythema multiforme, and related with cervix carcinoma and Atherosclerosis (AS). An important advance in our knowledge of HSV infections has been the ability to distinguish between HSV-1 and HSV-2. HSV-1 is more frequently associated with nongenital infection, while HSV-2 is associated with genital disease. HSV has two unique biological properties that influence human disease. Although HSV-1 and HSV-2 are usually transmitted by different routes and involve different areas of the body, there is an overlap in the epidemiology and clinical manifestations. Virus is transmitted from infected to susceptible individuals during close personal contact. There is no seasonal variation in the incidence of infection. Because HSV infection is rarely fatal, and HSV...
|
PDF Full Text Request