Quantitative Study Of Dynamic MR Perfusion Weighted Imaging Compared With Pathology-feasibility In Rabbit VX2 Liver Tumor Model

Objective:Hepatocellular carcinoma (HCC) is one of the most malignant carcinomas among primary hepatic carcinomas in our country. The incidence rate and death rate have beening increased in recent years. But the etiological factors and rationale of HCC are still unclear.Perfusion weighted image (PWI) has been applied by clinical diagnosis and basic research succeesfully in central nervous system, as developping functional magnetic resonance imaging in recent years. But there were few experimental research reports in the study of liver diseases.The obseration and investigation of pathology have been developed from plain pathological morphology to integrate the changes of histological types in morphology and immunohistochemistry with the development of the techniques of modern molecular biology, such as microvessel density (MVD) and vascular endothelial growth factor (VEGF).We established rabbit VX2 liver tumor model and compared quantitative indices of PWI to pathologic indices of VEGF of immunohistochemistry during the process of rabbit VX2 liver tumor model growing, and to evaluate whether quantitative study of mean time to enhance (MTE ),maximum slope of increase (MSI) from PWI could...