Correlation MRI Of Acute Cerebral Venous Thrombosis And Pathologic Changes: An Experimental Study

ObjectiveTo establish a suitable model with of acute cerebral venous thrombosis (CVT) by simulating acute clinical pathological changes of cerebral venous occlusion. To explore the method of cerebral functional imaging of CVT. The results correlated MR with histological changes are got to further research pathophysiological mechanisms of acute cerebral venous thrombosis. Methods 1. Establishment of rat model of acute cerebral venous thrombosisWistar rats were randomly grouped A,B,C. They were injected 10% Chloral Hydrate (360mg/Kg weight). After succeedly anesthetized, heads of rat were fixed on stereotaxis operation table by prone position. Head skin was cut medially for 1.5cm on center and exposed anterior fontanel and coronal suture. They were drilled open frontal bone and parietal bone along longitudinal suture with burr drill, meanwhile, persistently cooled in tresis vulnus. Port of bone was designed for 6x9mm and deep to surface of cerebral dura mater , but brain tissue was not damaged. SSS was explored and ligated on both sides. 21 rats of group A were slowly injected thrombus formation factor 150/μl by microdosis injector. Along SSS axis, as far as possible more cortex veins were embolismed. When SSS was present redness and solid blood clot, microdosis injector was withdrawed. After pulling out injector, puncture point had no reactive hemorrhage. 7 rats of group B were merely ligatedSSS, but not...