Studies Of Xining Formula's Curative Effect To Insufficiency Of Both Spleen And Kidney Type Of Osteoarthritis Of Knee

Osteoarthritis of knee is an arthropathy characterized by hyperosteogeny due to degenerative articular cartilage. It is a common disease of middle- and old-aged people, of which incidence is on a steady increase along with longer life span and increasing number of old people. Patients with osteoarthritis of knee suffer a lot in daily life for swelling and painful knee, however effective treatment to reverse hyperosteogeny or check the deterioration has not yet been available. Since TCM has certain advantages on it, this research summarized the diagnosis and treatment of osteoarthritis of knee on the basis of TCM understanding and study development of modern treatment. Meanwhile research methods of parallel control and randomized group were adopted and objective evaluation was made of XINING Formula's clinical effect on walking pain due to osteoarthritis of knee with deficiency of liver and kidney.Firstly, after arranging systematically previous literature of TCM, it holds that osteoarthritis of knee is based mainly on the deficiency of liver and kidney and precipitated by sprain, strain and invasion by exogenous pathogens and that swelling and painful knee results from stagnation of Qi, blood and endogenous phlegm and damp as well as obstruction of meridians. Therefore, the treatment should highlight the following principles: invigorating Qi and replenishing blood, tonifying liver and kidney, supporting vital Qi and dispelling evil Qi as well as emphasizing root causes and branch symptoms.Then through studying literature of western medicine, it believes that osteoarthritis of knee should be diagnosed with combination of clinic examination and radiology and that evaluation of degree of condition and integrative treatment of TCM and western medicine should be stressed to enhance therapeutic effect. The treatment of osteoarthritis of knee is targeted at improving blood circulation, reducing intraosseous pressure, inhibiting activated cell factors and growth factors, eliminating oxygen free radicals, increasing hyaloplasmic acid of local tissues to protect impaired cartilage cells. In addition, this thesis introduced gene therapy that is still under the stage of animal experiment, in which therapeutic gene is transplanted into affected joint. Therefore, it is promising in clinical application.In clinical research, clinical effect of XINING Formula, taken walking pain as chief effect index, on treating osteoarthritis of knee with deficiency of liver and kidney was compared with Votalin. There were 20 cases in treatment group and 20 in control group. The results showed that XINING group improved significantly in terms of walking pain, morning stiffness, the severity of stiffness and knee activities during climbing upstairs and downstairs after treatment, which had no significance comparing with Votalin group. Walking pain was improved with XINING Formula in slow start which then showed similar effect with Votalin in the 4th week of treatment and had the tendency of better effect in improving general conditions in the 4th week with 85% totally effective rate. The result in safety showed that gastrointestinal discomfort in XINING group was less than that in Votalin group, which indicated this formula was better in safety.