Experimental Study On Mechanism Of HA/CollagenI Composites's Osteoinductivity And Enhancement Of Spinal Fusion In Rabbit

Objective Hydroxyapatite/collagenI biomimetic composites' s structural characters, biodegradable properties, Chemical composition and crystallite size were similar to that of natural bone. Previous study about hydroxyapatite/collagenI showed that this kind of biomaterial had good biocompatibility. In recent years, some researchers found that hydroxyapatite/collagenI composites could induce new bone tissue formation in non-osseous site or environment. This kind of biomaterial have been one of the most popular areas of investigation during the past few years. Hydroxyapatite/collagenI biomimetic composites have been successfully used in long bone defects, but rarely used in biologic and biomechanic environment of spine. In order to investgate the mechanism of the hydroxyapatite/collagenI composite's biocompatibility, osteoinductivity and heterotopic bone formation ability, the biomaterials were employed as test materials in this study. Different methods were used to study the materials' s characters. For further clinical use, we had detected the enhancement of spinal fusion in rabbit in this study.Methods Hydroxyapatite were made under low temperature. After mixed with collagen I, the hydroxyapatite/collagenI...