The Clinical Studies Of Surgery Combined With Chemotherapy And Differentiation-inducing Therapy Of Advanced Ovarian Serous Cystadenocarcinoma

Objectives :To observe the change of ultrastructure of advanced ovarian serous cystadenocarcinoma cell combined of differentiation -inducing therapy by N-(4-carboxyphenyl) retinamide with conventional surgery and chemotherapy. To analyse the correlativity of Spk2 and P27^Kipl expression in ovarian serous cystadenocarcinoma . To investigate the relationship between the expression of Skp2 and P27^Kipl and the change of ultrastructure with, the serum level of CA125 and the survival rate of cystadenocarcinoma patients.Methods: Thirty-seven cases of advanced ovarian serous cystadeno- carcinomas in gynecology department of Yuhuang Ding Hospital of Yantai from the year 2000 to 2005 were randomly divided into two groups: experimental group (EG) with 20 cases and control group (CG) with 17 cases. All patients were identified as stage III of ovarian serous cystadenocarcinoma by laparoscopic evaluation, during surgery fulgerizing the metastasis sites in...