Relationship Between Serum Paraoxonase 1 Activities, Gene L55M Polymorphism And The Angiographic Characteristics Of Coronary Arteries In Chinese Patients With Coronary Heart Disease Complicated With Hyperglycemia.

Background and purpose:The pathological basis of type 2 diabetes(T2DM) complicated with coronary heart disease(CHD) is atherosclerosis, which precipitates myocardial infarction. The morbidity and mortality of CHD in diabetes mellitus are much higher.Many researches suggested that oxLDL played an important role in the formation and development of atherosclerosis. PON1 can protect LDL from being oxidized and thus delay the development of atherosclerosis. In this study, we used coronary angiography to investigate characteristics of coronary pathological changes and P0N1 and oxLDL activities, and try to establish the relationships between them in patients with CHD complicated with T2DM and with impaired fasting glucose(IFG). So that we could provide evidence for early prevention and treatment of diabetes and CHD.Subjects and methods:Subjects:284 patients hospitalized in the First Affiliated Hopital of Shantou...