Basic And Clinic Research Of MR Spectroscopy In Myocardial Ischemia

Magnetic resonance spectroscopy (MRS) is the only non-invasive means for the time being in detecting the changes in particular chemical compounds in animal or human body. With advances in MRS technology in the last decade,MRS has evolved from a method mostly involved with in vitro organ study or experimental study using animals into a technique mature enough to be recommended for clinical use. The FDA of the U.S.A. ratified the clinical application of MRS in 1995. Recently myocardial ischemia has become a focus of intensive investigation for those engaging in this field of research. ³¹P MRS has been used for several decades as an analytical tool in cardiac research and is quickly emerging as a diagnostic tool, due to its ability to continuously and noninvasively monitor levels of high energy phosphates, inorganic phosphate, and intracelluar pH in localized regions of the myocardium. However, the literature of applied studies on myocardial ischemia is sparse, which is thought to be attributable to cardiomotility and the lack of a proper MRS spatial localization technique. As a result the investigation of myocardial ischemia using MRS is still in its infancy in terms of the development stage. Based on the systematic experimental study of myocardial ischemia, the present study which is a pioneering work in China is undertaken as a clinical investigation of myocardial ischemia and dilated cardiomyopathy (DCM).The Objectives of the Present Study are:...