Expression Of P16 In Human Laryngeal Carcinoma And Inhibitory Effects Of Wild-type P16 On Human Laryngeal Carcinoma Cell Line

Laryngeal carcinoma is one of the most common malignant tumors in the world, and has very high morbidity and recurrence rate. It's one of the toughest conditions in laryngology. The study of molecular biology showed that the genesis of cancer correlated closely with the activation of cancer gene, the devitalization of cancer suppressor gene, and the lost control of cell cycle regulation. The p16 gene, discovered in recent years and consisting of 3 exons and 2 introns, was located in 9p21. The coded protein P16 was identified as a major part of Cyclin Dependent Kinase 4 inhibitor (CDK4I) in cells. It is the key control protein in cell cycle regulation network. Nowadays it has been found out that a number of cancers and cell lines have pl6 deletion and mutation, however, few reports about the relation between pl6 expression and laryngeal carcinoma have been made.In this report, we discussed the relationship between the expression of p16 gene and the genesisand progression of laryngeal carcinoma; the applying value of p16 gene in diagnosis and prognosis of laryngeal carcinoma; and the feasibility of p16 gene for gene therapy of laryngeal carcinoma. The main methods and results are as follows: 1. The expressions of P16 in 75 cases of laryngeal squamous cell carcinoma...