| The success of high specificity and affinity of anti-human hepatocellular carcinoma monoclonal antibody provides a new approach for hepatoma specific detection and therapy. In this work, 99Tcm and 188Re-labeled hepatoma McAb fragment HAb18 F(ab')2 for radioimmunoimaging and radioimmunotherapy were studied, and apoptosis in HCC cell line induced by 188Re-β irradiation was also discussed.1. Direct 99Tcm labeling of anti-hepatoma monoclonal antibody fragment HAb18 F(ab' )2 for hepatoma radioimmunoimagingTo establish a modified direct method for 99Tcm labeling anti-hepatoma McAb fragment HAb18 F(ab')2, The stability, biodistribution and imaging were assessed. HAb18 F(ab')2 was labled with 99Tcm by direct lableling approach using stannous/ glucoheptonate (Sn2+/GH) as reducing agent. Ellman's reagent was used to determine...
|
PDF Full Text Request