Osteosarcoma Immunotherapy Induced By Fusion Cells From Macrophages And Osteosarcoma Cells

Along with the development of cancer research, the traditional operation scheme have been changed in many ways, that makes the local control of osteosarcoma become possible. But the almost 40% lung metastasis tends to result in treatment failure in spite of combined with radiotherapy and chemotherapy.The findings of tumor specific antigen recognized by CTL, especially the melanoma antigens MAGE and MART, have promoted the active immunotherapy in large extent and then several clinical trails are in progress. The immunotherapy based on a greater appreciation of the mechanisms by which tumor-specific cytolytic cells are generated is becoming a new approach in cancer treatment.Central to the induction of CTL responses are professional antigen-presenting cells, including macrophages and dendritic cells, which present tumor antigen to the immune system in the context of major...