Study Of Reducing-calcification Monocuspid Patch Of Pocine Pericardia

The monocuspid patch is required to widen the outflow tract of right ventricle for the patients with complex congenital heart disease of obstruct in outflow tract of right ventricle.It can prevent insufficiency of. pulmonary artery. In monocuspid tissues used now, pericardia autografts are easy to rull up, bovine pericardia more thick and easy to obstruct the orifice of the outflow tract, porcine valves difficult to be chosen the proper size. The incidence of calcification and function failure of these monocuspid tissues is rather high after implantation. It is a serious problem affecting the long-term result. Up to now, the ideal reducing—calcification method of cardiac bioprostheses hes not been found in the world. In the study, the glutara(?)dehyde(GA) treated porcine pericardia were modified chemically with epoxy chlopropane(EC). The new monocuspid patches were made and implanted in the outflow tract of right ventricle in dogs (n=10). The GA or chloroacetic treated monocuspid patches of porcine pericardia were used as the control groups. At 6 month after implantation, the calcium of the samples was detected qualitatively, quatitatively and ultrastructurally. It is found that the chemically modified monocuspid patch of porcine pericardia with EC can reduce the calcification significantly and keep good function of monocusp. The systematic study of tissue stability, histology, ultrastructure...