The Experimental Study On Manifold New-types Surface Modified IOLs

Success or failure and complications of extracapsular cataract extraction(ECCE) with implantation of a posterior chamber intraocular lens(IOL) depend on IOL itself to a great extent. The biocompatibility of IOLs has been studied by many authors. In order to get a better biocompatibility polymethylmethacrylate (PMMA) IOL surfaces were modified and observed in vivo and vitro.Part I The experimental study on F-heparin surface modified IOLsAt present PMMA is still the most common IOL material used. PMMA IOLs led to some degree of inflammatory response, foreign body reaction and complications. In our former study the technique of carrier energy ion beam combined with low temperature and low pressure plasma was used to modify the surfaces of PMMA IOLs with F ions and the heparin solution. In vitro, it was confirmed that the F-heparin modified IOLs(FHM IOLs) possessed better biocompatibility than that of PMMA IOLs. In this study the nonhuman primate animals-monkeys were chosen to implant FHM IOLs for one year to compare the results with PMMA IOLs. Pharmacia heparin surface modified (HSM) IOLs were also used as a control.Twenty monkeys were used and classified into 5 groups. In normal group two monkeys (4 eyes) were not operated. Operations were done on all of the monkeys except in the normal group. In Control group 1, 10 eyes of 5 monkeys were implanted with PMMA IOLs. Control group 2, 6 eyes (3 monkeys) were implanted with HSM IOLs. Experimental group 1, 10 eyes(5 monkeys) were implanted with F(3.5× 10¹⁴ions / cm²)-HM IOLs. Experimental group 2, 5 monkeys(10 eyes) were implanted F(6.0 × 10¹⁴ions / cm²)-HM IOLs. All of the eyes were examined by slitlamp microscope, ophthalmoscope and schiotz tonometer under general anesthesia at postoperative 15, 30, 60, 90, 180, 360 days. At different periods postoperatively aqueous from anterior chamber was aspirated to...