| Background and Research Strategy:The formation of scar is the common complication of postburning. Although there are various treatments for this disease, the results are far from satisfied.. Recently the molecular mechanism of the synulosis is clearer to us and many researchers have tried to carry out gene-therapy in this area.The major feature of fibrosis is the excess deposition of ECM (extracellular matrix), which includes collagen, non-collagen glucoprotein and proteoglycans. Both quantity and quality of ECM are found to have a magnificent changes when fibrosis developes in which the amount of collagens, especially of collagen I, are increased by 3-8 times than that in normal tissues.It has been found that LH (lysyl hydroxylase) is associated with both of the formation and the stablilization of collagen. LH includes LH1, LH2, LH3 which coded by PLOD1, PLOD2,PLOD3 respectively, LH2 is most closely related to fibrosis.LH resides in the human tissues extensively and its major physiologic function is hydroxylate lysine in the collagen protein molecule to hydroxylysine, followed by spuring the formation a stablilized covalent cross-link of inter-molecule.The genesis of fibrosis is characterized as the excess accumulation of collagen. During the synthesis of collagen, the formation of the inter-molecule cross-link is an important post-translational modification step. The formation of cross-link has two styles: one comes from allysine pathway, the other from hydroxyallysine pathway that includes the formation of HP (Hydroxylysylpyridinoline) and LP (lysylpyridinoline).In the normal organ such as skin, liver, and lung,,the cross-link mainly comes from allysine pathway, this kind of link is apt to degeneration. If this kind of link is transformed to...
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