Synthesis And Characterization Of The Controlled Release Membranes In A Transdermal Drug Delivery System

The transdermal drug delivery system (TDDS) is one type of the drug administrations that drug gets into blood circulation by the absorption of skin and reaches effective blood level for the purpose of preventing disease and therapy. TDDS is an important field in development of new types of drug deliveries. However, the controlled release membrane as a key part of TDDS has become the bottle neck of development of TDDS. The traditional methods of preparation of controlled release membrane include boasting plastics molding, pressing spread molding and flowing spread molding.These traditional methods have various shortcomings, such as poor quality, environmental pollution and rare types, so that the traditional methods can't complete the purpose of more and more drugs administering TDDS. Aiming at the shortcomings in the controlled release membrane, a clean and pollution-free technology of ultraviolet light polymerization is introduced to synthesize the controlled release membrane. The mixture of acrylate and acrylamide monomers with photo initiator, were treated under strong power ultraviolet radiations to synthesize the copolymer membrane. The drugs with different properties of physics and chemistry were used as testing drugs in order to analyze the properties of the permeation of the copolymer...