Diclofenac Film Agent Selection And The Release Of The Performance

Transdermal delivery system is designed to provide controlled continuous therapeutic system of drugs via administration across skin. It is well known as the third generation formulation after oral delivery and injection. Because of its avoidance of the toxicity affection of gastrointestinal physiological function, it is deeply welcomed by medical affairs people and sufferers. Especially for some side affection medicals, the use of controlled membrane will get better effect, but the problems to be solved are the storage of medical and technologic conditions, which are need for medical release. Among of them, the gel, which is use for storing medical and the membrane, which lets medical go through are important technologic condition. We choose Dichlofenac as the research medicine, because it is a good non-steroidal anti-inflammatory drug. It is use for in the treatment of rheumatoid arthritics and other rheumatic disorders, but because of its short biological half-life, absorption and elimination promptly, it is use in the controlled membrane research. The research results are as following:1. Dichlofenac diffusion property from Fl (Carbopol-940, crylic acid colophony, hereinafter for short is Fl) and F2 (Alginate sodium, hereinafter for short is F2) vehicles was studied through micropore filter membrane. It is found that the diffusion rate of F2 is faster than that of Fl. In Fl vehicle, Dichlofenac is existed in the form of molecular. In F2 vehicle, Dichlofenac is existed in the form of ion. Through micropore filter membrane that small size drug and water can flow freely, the release rate of the ion Dichlofenac is faster than that of the molecular Dichlofenac. The factor influenced on release rate is the form of Dichlofenac existed and has little relationship on the different vehicles.2. 2% Azone can enhance the absorption of Dichlofenac across skin. The drug concentration change through skin under the effect of Azone is 3 to 5 times than common.3. Evaluating the release amount of Dichlofenac from Fl, F2 vehicles through the polymer membranes (EVA> PU> PVA), we found that the diffusion rate of Dichlofenac through the polymer membranes was influenced by the distributed drug amount mto the polymer membrane, in other word, the drug solubility in the polymer membrane. The molecular form of Dichlofenac is distributed easier to the hydrophobic membrane, on the other hand, the ion form of Dichlofenac is distributed better into the hydrophilic and polar membrane.4. EVA and PU membrane can be made of Dichlofenac penetrate through skinVIIIwith constant speed. The cumulative permeation amount of Dichlofenac through PU membrane and skin. We choose PU membrane as the rate-controlled membrane of Dichlofenac transdermal patch..