Protective Effections Of Immunonutrition For Intestinal Mucosa In Scalded Rats And Application In Burns Patients

Background and Research StrategyThe stress response after burns would arouse ischemic damages in intestinal mucosa and induce endotoxin/bacteria translocation, which affected complement system and produced redundant degradation products, and resulted to obviously lower in visceral bloodflow,those materials caused vicious cycle between inflammatory factor and host. So Wilmore preferred that intestine was the center organ at stress state; they thought barrier dysfunction in intestine would promoted occurrence of SIRS and MODS by a series of cascade reactions.As intestinal tract were the center organ of hypermetabolism after burns, the intestinal mucosa were damaged without sufficiently nutritive substrates, which effected absorption and utilization of nutritive substances, and restrained immunological function indirectly, At the same time endotoxin/bacteria translocation were aggravated, systemic infection and damaged in organ' s function were induced.Because of severely damage in tissue and changes secondarily in neuroendocrine after burns, there proceeded a series of complicated diversify in metabolism among glyco,proteins and fat, tissue disintegration were aggravated, protein lossed greatly, on the other hand, the requirement for nutritive substances were augmented for wound healing. So effective nutritional support became a central aspect of treatments in burns patients.