Synsesis And Primary Study Of Biodigradable Poly(Sebacic Anhydride) And Poly(Ethylene Glycol)-Poly(Sebacic Anhydride) Block Copolymers As Drug Carriers

In recent years, biodegradable polymeric materials have been found to be useful in drug delivery, bone and cartilage repair, and tissue engineering applications. In these materials, polyanhydride was a kind of biodegradable polymer, which attracted the interest of many researchers, because it was biocompatible and the rate of degradation was easily controlled. In this dissertation, poly(sebacic anhydride) (PSA, Mn = 40,000)) was synthesized. Besides the homopolymer, diblock, triblock, 3-armed, and 4-armed poly (ethylene glycol)-co-poly(sebacic anhydride) block copolymers were also synthesized. Except the diblock copolymers, the others have not been reported yet. The self-aggregation behaviors of these copolymers in aqueous solution were studied. Furthermore, drug release profiles from the PSA microspheres and copolymer micelles were studied.PSA prepolymers were synthesized with acetyl anhydride and sebacic acid. The chemical structure of prepolymer was characterized with 1H NMR, ^13C NMR and FTIR, and the results confirmed that the product had the expected structure. In addition, the elementary composion obtained by elementary analysis was close to the result calculated from ¹H NMR.