The Experimental Study On Glucocorticoid-Induced Osteoporosis Prevented And Treated By JIANGU Granule

Objective: This experiment embarks from the molecular level,observation Chinese native medicine JIANGU granule to GIO sickness forming process in VEGF and collagen I mRNA expression level influence,thus discusses its preventing and controlling glucocorticoids-induced osteoporosis sickness mechanism.Methods: In order to discuss the JIANGU granule treatment GIO molecular action mechanism, this research takes the osteoporosis sickness animal experimentation model by the glucocorticoids-induced induction domestic rabbit, through HE dyeing research Chinese native medicine JIANGU granule to vacancy bone sunken number influence; Through the immunity histochemistry technology,observes the blood vessel bast growth factor in the bone tissue expression. Through home position hybrid technology,in mRNA member level research, collagen I mRNA distribution and expression.Result: the Chinese native medicine JIANGU granule may make the vacancy bone sunken number reduction. The immunity group demonstration, the JIANGU granule may enhance VEGF in the bone tissue expression level. The home position hybrid demonstrated collagen I mRNA mainly distributes in the osteoblast plasma center, and utilizes the JIANGU granule to treat the latter collagen I mRNA expression level to enhance。Conclusion: The Chinese native medicine JIANGU granule may through to VEGF and I collagen mRNA regulation,thus promotion bone formation, preventing and controlling glucocorticoids-induced osteoporosis...