Clinical Research Of Types Of Syndrome Of TCM Of Hepatitis Hepatocirrhosis And Treatment Studies Of The Ruan Gan Xiao Ji Tang

Research ObjectiveTo explore microscopic quantization' s serological index of the type of syndrome ofTCM of hepatitis hepatocirrhosis by researching the rule of the categorical identification interms of TCM. Bring TIMP-1 into the associating research of the syndrome-type of TCMof hepatitis hepatocirrhosis for the first time,and observe the clinical curative effect, andpreliminarily approach the probable mechanism.Research Methods1.Choose 146 patients of hepatitis B and C hepatitis hepatocirrhosis that coincide withreceipt standard and eliminant standard, and make patients do the questionnaire whenthey are admit or first clinic. The symptomatic form are made out by patients led by doctors;and the physical symptom is marked by doctors; tongue demonstration and pulse tracingsare diagnosed and anslyzed by traditional method; two associate chief physician above willfinal decide the types of syndrome of TCM,which including endoretention of damp heat,depression of liver-QI, damp abundance due to splenic asthenia, hepatic and renal yindeficiency, asdthenic splenonephro-yang, stagnation of blood all 6 types. TIMP-1 contentin blood serum, index of hepatic fibrosis in blood serum(collegen typeⅣ, hyaluronic acid,procollagenⅢpeptide, laminin), liver function test that include total bilirubin(TBIL),alanine aminotransferase(ALT), aspartate aminotransferase(AST),albumin(ALB),globulin(GLB), prothrombin activity(PA) of all the subjects are examined on an emptystomach,and their liver function would be classified into A,B,C three levels in accord withthe Child-Pugh level.The correlation between the serological index and the type ofsyndrome of TCM of hepatitis hepatocirrhosis is analyzed after the results come out.2.Randomly devide the 146 patients into 2 (?)roups by the randomized table: the RuanGan Xiao Ji Tang group(treatment group) and Western medicine routine treatmentgroup(control group),73 patients each group. The treatment group patients adopt Ruan Gan Xiao Ji Tang,which is decocted in water for oral dose once daily. The control group adopt 2glucurone ter in die,and supply albumin to the Hypoproteinemia patients,supplymonosodium glutamate or arginine to the hepatic encephalopathy patients, supplydiureticum to the abdominal dropsy or edema of lower extremity patients who among. Bothgroups are successive administration for 3 months. Record the amelioration of clinicalsymptom and recheck the serological index above-mentioned.3. Process the experimental data statistically and express as±SD,use t-test tocomparison among groups,the difference is significant when P＜0.05.Research Results1. The clinical research of Hepatieis and hepatocirrhosis on Herbalist Type.(1) The TIMP-1 GUIDELINE ofhepatocirrhosis sufferers on different Herbalist Type.There are many remarkable different TIMP-1 between every type of hepatocirrhosis and thecontrol group.The high-to-low change of TIMP-1 on every type is Hepatic and renal yindefinciency＞Asdthenic splenonephro-yang＞Stagnation of blood＞Damp abundance dueto splenic asthenia＞Endoretention of damp heat＞Depression of liver-QI.By comparingone to another,it is found that there are many remarkable differences between Hepatic andrenal yin deficiency and Damp abundance due to splenic asthenia.(2) The Guidelines of hepatocirrhosis and hepafibrosis on different herbalist type.TheGuidelines of hepafibrosis on Hepatic and renal yin deficiency—HA, PC-Ⅲ,are remarkablydifferent from the ones on Endoretention of damp heat. HA, PC-Ⅲ, LN andⅣ-C onStagntion of blood are higher than the ones on Endoretention of damp heat.What ismore,the difference value much.(3) The Child-Pugh classification of hepatocirrhosis on differentHerbalist Type. On Level A of Child-Pugh classification, Endoretention of dampheat is the commonest to see, and the second is Depression of liver-QI. Theyboth are more different and significative than other types. In Level B ofChild-Pugh classification, there is few remarkable difference among all thetypes and the difference values little. In Level C of Child-Pughclassification, Hepatic and renal yin deficiency is the commonest to see. Thedifference between Hepatic and renal yin deficiency and other types, valuemuch. We can find that the Level C of Child-Pugh classification is more commoneron Hepatic and renal yin deficiency, Stagnation of blood and Asdthenicsplenonephro-yang.2.The clinical research of the therapy to hepatitis and hepatocirrhosis withYunganxiaojitang.(1) Compared the total effective rate after the therapy to the two groups of sufferer, it issaid that compare by the total effective rate of the treatment with the control group: X'=66.20 P＜0.05. (2) The compare of the TIMP-1 change between before and after the theratp to thetwo group sufferer.The result said that among the suffers on Endoretention of damp heatand Damp abundance due to splenic adthenia about hepatocirrhosis,the difference ofTIMP-1 between the treatment group and control group:t=2.332,t=2.441P＜0.05,valuesmuch.(3) The change of Guideline about hepatic fibrosis between before and after therapyto the two groups of sufferers PC-Ⅲof the treatment group had dropped a lot aftertherapy. Compared to the control group: t=3.267,P＜0.05.The difference values much.But the change of HA, CIV, LN between before and after therapy to the two group changea little and the differenct values little.(4) The clange of the liver function between before and after the therapy to the twogroups. View list 6.IN list 6,it results that in the therapy to the Endoretention of dampheat and Damp abundance due to splenic asthenia.The treatment group is better thanthe control group on dropping ALT,AST and esalting ALB. The difference values much,P＜0.05.Conclusion1.The reciprocity are significant of TIMP-1,liver function index and level amongdifferent types of syndrome of TCM of hepatitis.Sorting the TIMP-1 value of differenttypes of syndrome from larger to minor is: hepatic and renal yin deficiency＞asdthenicsplenonephro-yang＞stagnation of blood＞damp abundance due to splenic asthenia＞endoretention of damp heat＞depression of liver-QI. The balue of TIMP-1 can be an indexthat reflect the severity of the hepatocirrhosis state, and it's directive significant to theprognostic evaluation. Major Child-Pugh liver function level A is the type of "endoretention of damp heat", and most Child-Pugh liver function level C is the type of "hepatic and renal yin deficiency"2. Ruan Gan Xiao Ji Tang, act by inhibiting the TIMP-1 level, can availably improvethe clinical syndrome and physical sign of hepatitis hepatocirrhosis' patients of "endoretention of damp heat" and "damp abundance due to splenic asthenia" types, isvaluable to further exploit and research.