The Relevant Research Between Regulating Ying And Wei To Restore The Normal Sleep Rhythm And Influencing In The Sleeping Factors

Objective:To investigate pharmacodynamics and pharmacology mechanism of the sleep-related night-prescription and the arousal-related day-prescription to treating insomnia, which using the theory of time choosing-homeopathy and harmonizing nutrient Qi and defensive Qi. Methods:The effect of the sleep-related night-prescription and the arousal-related day-prescription in treating insomnia rat was studied using a sleep-disturbed model developed by placing rats on a small platform suspended water by interruptable sleep deprivation. Alprazolam was positive control. The responses of the insomnia rat to time choosing-homeopathic remedy was recorded in following aspects: the general condition, the autonomic activities, study and memory ability, sleep phase of electroencephalogram, sleep related material such as 5-HT,NE and cAMP, biological clock gene expression in SCN. Results:the treatment group improved obviously in treating insomnia compared to the control group. the treatment group reduced the nerve excitability of independent activity, enhanced the study and memory ability, extended the sleep time and promoted deep sleep(SWS2), improved sleep structure, increased the content of 5-HT and cAMP and falls the content of NE, corrected the disorder of day and night rhythm by regulated biological clock gene expression. Moreover, Each parameters of the treatment group was prior to the control group, the sleep-related night-prescription and the arousal-related day-prescription respectively. Conclusion: The time choosing-homeopathy of the sleep-related night-prescription and the arousal-related day-prescription coordinated mutually can promotes the normal sleep rhythm restoration, compared to the Alprazolam, the sleep-related night-prescription and the arousal-related day-prescription. The mechanism possibly has the relations with adjusing sleep correlation material content and regulating biological clock gene expression in SCN. In conclusion, Time choosing-Homeopathy and harmonizing nutrient Qi and defensive Qi are very important principles to the insomnia, and the sleep-related night-prescription and the arousal-related day-prescription are very effective to the insomnia too.