The Efficacy And Mechanism Study Of Huganyin Preventing And Treating Acute Drug-induced Disease

Objective: To observe the effect of Huganyin on the Acute Drug-induced Disease and explore the mechanism of it. Methods: Clinical study :60 patients with Acute Drug-induced Disease were divided into two groups at random:the treatment group and the control group. The treatment group was given Huganyin,the control group was given Tiopronin Tablets. Observe the clinical efficacy. Experiment study: 90 normal KD mice were randomly divided into 9 groups. The Acute Drug-induced Disease rat Model were established with CCl4 and AP. Observe the decoction effects of Huganyin on ALT, AST, TNF-α, SOD , GSH, CYP2E1, fat content and cell construction. Results: The treatment group's main effective rate of the syndrome of TCM,the results of liver function test are better than the control group's. Huganyin can improve SOD and GSH, reduce TNF-αand MDA, restrain the expression of CYP2E1, correct lipid metabolism mess. Conclusions: Huganyin is a effective drug of treating Acute Drug-induced Disease, it can moderate clinical symptom, alleviate the patients'sufferings rapidly. The mechanism contains improving SOD and GSH, reducing TNF-αand MDA, restraining the expression of CYP2E1 and correcting lipid metabolism mess.