The Experimental Studys And Clinical Studies Of TongFeng Instant Powder On Treating Acute Gouty Arthritis

1.Objectives:Through this study,improve the preparation of pre-ciinical observation system and the acute toxicity,pharmacodynamics pharmacodynamics research and the main experiment,to study Chinese medicine of TongFeng Instant Powder as well as to provide experimental basis for clinical application and theoretical basis.2.Materials and methods:(1).The major pharmacodynamics investigations:to comparatively observe the effect of TongFeng Instant Powder on blood uric acid metabolism through-experimental hyperuricemia rat model;to comparatively observe the effect of TongFeng Instant Powder on arthrositis induced by specific sodium urate through the rat arthritis model induced by sodium urate.(2).It has been proceeded of acute toxicology test of TongFeng Instant Powder.(3).To proceed clinical effect observation of the drug granules of TongFeng Instant Powder to acute gouty arthritis.vs.Colchicine.3.Results: (1).Indicated by the major pharmacodynamics researches:the drug.granules of TongFeng Instant Powder can significantly decrease the blood uric acid of the mice hyperuricemia model induced by fed with adenine and ethambutol to induce hyperuricemia;it is outstandingly to inhibit the swelling and pain of joint and inf lammatory reaction of the rat arthritis model induced by sodium urate crystal;It can ipromote the excretion of uric acid,and relieve the joint inflammatory reaction.(2).Indicated by the clinical effect observation to acute gouty arthritis:the drug granules of Instant Powder decrease blood uric acid,improve the articulation function,relieve erythrocyte sedimentation,reduce the ESR,C-reactive protein andthe regulation of blood lipids,no significant side effects and adverse reactions,and the collectivity effect is better than Colchicine.(3).Indicated by the acute toxicity trial to this new preparation:it is safe to take the drug granules of TongFeng Instant Powder 36g per day(about 0.8g/kg).4.Conclusions:(1).The drug granules of TongFeng Instant Powder can decrease the blood uric acid of the patience,drop the blood lipo,decrease the blood consistence,improve hematological flow and transform propert,infiuence the formed gout nod,has the function of relieving the primary and secondary symptoms at the same time,the treatment of the tip and root to chronic gouty arthritis,and its collectivity effect is better than probenecid.(2).The drug granules of TongFeng Instant Powder have preferable,antiinflammatory,antioncotic and analgesic action and promotingblood circulation.It is effective on treating both acute arthritis without toxic effect.