| To investigate the preventive effects and its mechanisms of lycopene supplementation for 12 wk on vascular atherogenesis induced by hyperhomocysteninemia in rats. The results showed that diet plus 3% L-methionine can induce hyperhomocysteinemia and premature atherosclerosis in rats. Lycopene exerts an antiatherogenic effect in hyperhomocysteninemic rats by inhibiting oxidative stress through quenching reactive oxygen series and enhancing SOD mRNA expression in liver and SOD, GSH-Px activities in liver and serum, downregulating the expression of inflammatory agents through quenching reactive oxygen series and inhibiting activation of NF-κB.
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