Research On The Relationship Of Blooding Flow Impact And Aortic Wall: Stanford Type B Aortic Dissection

BackgroundAlong with the changes in modern spectrum, as a high rate of sudden death disease thoracic aortic dissection incidence rate increased significantly. But its pathogenesis is not clear. In particularly, why was dissecting prevalent in the thoracic aorta instead of the abdominal aorta? Why would be happened, Stanford type B aortic dissection tears always were found in the artery ligament region (aortic isthmus), it has been plagued by clinical medical doctors.We would find out the incidence of aortic dissection, when the wall has been studied with hemodynamic. For Stanford type B aortic dissection, We think that the mechanism of the tears in the region of ligament main artery (aortic isthmus) should be that Ligament regional arterial wall and structural characteristics of the flow characteristics of the interaction.ObjectOn the objective of pathogenesis of Stanford type B aortic dissection, which is needed that aortic dissection wall formation and flow correlation between the purposes of the study. It is hoped that the good parts of the wall and do a blood analysis, trying to find out the main factors of aortic dissection, to provide the basis for clinical treatment.StudyStudied Stanford type B aortic dissection pathogenesis, it must be flowed from the wall and the two-pronged found in the wall of blood under the Reconstruction laws, and the reconstructed wall flow heavy cloth patterns.1 Hemodynamic characteristic: the region of aortic artery ligament (RAALE).A. Human aortic blood flow velocity distributionB. Flow velocity distribution changesC. Membrane flow on the impact of the medial2 Mechanical characteristics: the wall of the region of aortic artery ligament (RAALE).A. Different mesoderm's smooth muscle cells were differencesB. Medial damaged animal modelC. Mechanical Properties: medial layers3 Relationship of blooding flow impact and aortic wall: Stanford type B aortic dissection.A. Single factor analysis of flow-sensitive factorsB. Single factor analysis of sensitive factors wallC. Two-factor analysis of blood flow and sensitive factors wall 4 AidsReal-time software aortic blood testsMethodsFlow: (1) Delphi programming language, "RAALE flow analysis system," applied research projects. (2) - functional ultrasound tests to be normal of 86 cases, 60 cases of patients with hypertension, Stanford type B aortic dissection with 43 cases of RAALE data and conducted using SPSS 12 statistical analysis. (3) Adoption of animals, the blood test RAALE characteristics.Wall: (a) issues through hierarchical culture membrane cells under the microscope observation that real-time quantitative method, at the gene level certification during the differences. (2) subject tests using animal models dissection specimens at the cavity wall of the ultimate stress, Conversion changes shape than numerical comparisons can be so analyzed RAALE dissection of the wall factors.Relevance: the topic using animal models, respectively factors and vascular wall factors, Observing RAALE Department formed Stanford type B aortic dissection, Mono factors for sensitivity analysis.Software: Delphi language-related software.Statistics: SPSS12 statistical software to analyze the data.ResultsBlood: (1) LSA lateral extension with the high-speed flow RAALE District crux of the descending aortic diameter radial extension phase pay from the perspective of the value of T, relatively fixed. (2) For the endovascular exclusion for Stanford type B aortic dissection patients, BD preoperative values greater than tumor patients, before and after the changes in the value of BD showed no significant difference and the tumor is less than BD values before and after the change is statistically significant. (3) The endometrial tear LSA distance less than the tumor Stanford type B aortic dissection patients The BD values are: normal preoperative There was a statistically significant difference, but after no statistically significant difference; intimal tear while the LSA distance greater than the mean tumor Stanford type B aortic dissection patients The BD values are: preoperative and postoperative with normal statistically significant differences.Wall: (1) Dogs RAALE smooth muscle cells (SMC) layered vitro success. Counting statistics through proliferation, membrane, and the inner layer of SMC proliferation count statistically significant differences compared to the average: the outer membrane zone "membrane middle district" inner membrane area. (2) Use of elastics ablation damage lamellar membrane fusion and linking hypertension, Dogs successfully established the Stanford type B aortic dissection pathophysiological model. (3) Using Universal Testing Machine for Stanford type B aortic dissection RAALE animal model of the cavity wall at the ultimate stress, through conversion, were to be false and outside wall of the cavity shape changes can yield, statistically. It shows a statistically significant difference in the medial layers.Relevance: high blood pressure and damage to the membrane formation of aortic dissection sensitive factors. By statistical analysis showed: aortic dissection in the formation of membrane lesions greatest contribution.ConclusionFlow: (1) there is a swirl RAALE District, the crux is the most high blood spots. (2) LSA lateral extension with the high-speed flow RAALE District crux of the descending aortic diameter radial extension phase pay from the perspective of the value of T constant angle. (3) LSA lateral margin of the aortic arch and the intersection of the high-speed flow of endometrial district center or tear away from the mouth numerical (B D), reflecting a drop of the aortic arch shape distortion of the change. (4) The use of constant angle T and BD value can be right aortic arch of vascular lesions trend forecast.Wall: (1) SMC in RAALE film which is artery wall mechanical properties are important determinants. (2) The outer membrane which RAALE District SMC Heterogeneity and Stanford type B aortic dissection occurred closely related. (3) Lateral membrane RAALE which lamellar zone mechanical properties of materials with different aortic dissection formation.Relevance: (1) Increase in blood factors, RAALE will rebuild the wall deformation. (2) Flow factors and aortic dissection is closely related to blood factors alone can not lead to aortic dissection. (3) Wall factors RAALE elastic membrane lamellar structural damage and Stanford type B aortic dissection formation. (4) Factors and the wall of blood factors are RAALE formation of aortic dissection necessary conditions. Which is the foundation wall of factors, blood flow is the only factor motivating factors.